Approaches to the Cephalotaxine Skeleton Using an Intramolecular Heck Reaction.

The asymmetric intramolecular Heck reaction in natural product total synthesis.

A highly enantioselective intramolecular Heck reaction with a monodentate ligand.

An efficient enantioselective intramolecular Heck reaction of cyclohexadienones, using readily available and modular TADDOL-based mono- and bidentate phosphoramidites as chiral ligands and not requiring any additives, has been developed. Excellent enantioselectivities up to 96% ee are reached for the first time in a Heck reaction with monodentate ligands.

An intramolecular organocatalytic cyclopropanation reaction.

Catalytic processes that form functionalized cyclic molecules represent a key transformation for synthetic organic chemistry. Recently, a number of organocatalytic processes have emerged that often provide excellent levels of both enantioand diastereocontrol for the synthesis of cyclic molecules. Our recent studies have identified the utility of ammonium ylides for carbon–carbon bond formation....

One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization.

An efficient, one-pot synthesis of 4-methylisoquinolines via a cascade Pd-catalyzed Heck reaction, intramolecular cyclization and isomerization has been developed. This reaction has a wide range of substrates with various functional groups, and the corresponding products have been obtained in good yields.

Ligand-free palladium-catalyzed intramolecular Heck reaction of secondary benzylic bromides.

A facile ligand-free palladium-catalyzed intramolecular Heck reaction of β-hydrogen-containing secondary benzylic bromides was developed, which affords pyrroline derivatives with good regioselectivities.